Main » Infectious diseases » Arthropod-borne Infection » Mucocutaneous Leishmaniasis
Photo 1. Early lesion of espundia. The lesions of mucocutaneous leishmaniasis are first evident as ulcers involving the mucocutaneous junctions of the mouth and nose.
Photo 2. Pharyngeal involvement. Ulceration often extends to the pharynx and soft palate, and the first symptoms may be related to tissue destruction in this area. This man had the scar of a large ulcer which apparently healed on his leg some 30 years before.
Photo 3. Destructive espundia. Gross destruction of the nose, including the septum and palate may follow inadequate treatment. In any case patients with this disease respond very poorly to any form of therapy.
Photo 4. 'Show' lesion in hamster thre months after inoculation. L. braziliensis, the causative organism of Espundia, is difficult to demonstrate in the lesions. Inoculation into the nose and feet of hamsters may result in the development of small nodules at the inoculation sites nine months or more later. Culture in vitro is very difficult. This is termed a 'slow strain' of parasite.
Photo 5. L. mexicana in hamster six weeks after inoculation. In comparison to L. braziliensis, L. mexicana and allied organisms rapidly produce large histiocytomas at the sites of inoculation within a few weeks. These parasites also usually grow very readily in NNN medium.
Photo 6. Skin biopsy techique. In doubtful cases skin biopsy can be taken using a skin punch. The material can then be examined histologically and an attempt made to culture the organisms in hamsters or in NNN medium.
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